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The left edge of your browser window becomes a multi-purpose button. It is infinitely wide because your mouse can continue to travel left, while the cursor will remain stuck to the edge of the screen.
For optimal usability, please make sure that your window in maximized.
The trick is to fling your wrist to the left. No accuracy or coordination is needed here. You could even do this blind-folded.
Then proceed to left/middle/right click the mouse as desired or rotate your mouse wheel.
This extension doesn't work on the Browser's Settings page and the WebStore page, because of Chrome's security policy.
Unlike other mouse gesture extensions, this extension doesn't require you to hold the mouse button down while moving it, which means less coordination required!